Explaining the technology
Innovative Solutions, Long-Lasting Results: Explore Hallura's Cutting-Edge Technology
Pioneering HA Fillers Excellence: Crafting Innovations to Shape the Future of Beauty.
Hallura offers a new horizon of aesthetic medicine that is safe, innovative, and biomimetic. Our cutting-edge technology, coupled with our team’s expertise, provides you with personalized treatments and long-lasting results.
Pioneering HA Fillers Excellence: Crafting Innovations to Shape the Future of Beauty.
Hallura offers a new horizon of aesthetic medicine that is safe, innovative, and biomimetic. Our cutting-edge technology, coupled with our team’s expertise, provides you with personalized treatments and long-lasting results.
Pioneering HA Fillers Excellence: Crafting Innovations to Shape the Future of Beauty.
Hallura offers a new horizon of aesthetic medicine that is safe, innovative, and biomimetic. Our cutting-edge technology, coupled with our team’s expertise, provides you with personalized treatments and long-lasting results.
Our
Revolutionary
Technology:
BiOLinkMatrix by Hallura™
At Hallura, we’ve redefined the landscape of hyaluronic acid (HA) dermal fillers through our groundbreaking patented technology known as BiOLinkMatrix. This innovative approach represents a significant leap forward in the field of aesthetic medicine, offering a unique solution for those seeking natural, safe, and long-lasting results.
With a foundation rooted in successful clinical trials and a steadfast commitment to natural beauty, safety, and effectiveness, Hallura’s BioLinkMatrix emerges as a guiding light for individuals seeking personalized, adaptive, and confidence-boosting aesthetic treatments.
WE ARE
FILLERS HA
BASED ON THE 2022 NOBEL PRIZE IN CHEMISTRY
FIRST TIME INTRODUCED TO THE AESTHETIC FIELD
BASED ON THE 2022 NOBEL PRIZE IN CHEMISTRY
FIRST TIME INTRODUCED TO THE AESTHETIC FIELD
THE REVOLUTION
developed the BiOLinkMatrix ‘lock-key’ crosslinking method, creating pure elasticity.
(1) Typical conditions for BDDE crosslinking: 52˚C for 3hrs. (2) Optimized conditions for BDDE crosslinking: low temperature, several days.
Product Features
| HLR-1 | HLR-2 | HLR-3 | |
|---|---|---|---|
| HA concentration | 4 mg/mL | 6 mg/mL | 8 mg/mL |
| Primary indications | Lips correction & enhancement | Filling & smoothing of wrinkles | Facial remodeling & volume restoration |
| Elastin % (vs non treated skin)³ | +104% | +54% | +38% |
| Collagen I (% vs non treated skin)¹ | +14% | +21% | +20% |
| Lifting Force⁴ | c.460 Pa | c.1,175 Pa | c.1,950 Pa |
| Product Integration | Distributed | Distributed | Distributed |
| Syringe Volume | 1 mL | 1 mL | 1 mL |
| Needle | 30G (UTWN) | 27G (UTWN) | 27G (UTWN) |
| Microcannula Recommendation | 25G | 22G | 22G |
| Composition | 4 mg/mL HA with 0.3% Lidocaine | 6 mg/mL HA with 0.3% Lidocaine | 8 mg/mL HA with 0.3% Lidocaine |
(1) Hallura, data on file, study reports – 22E5690, 22E5830, Elastin and Collagen stimulation 7 days post injection in a Human skin explant.
(2) Hallura, data on file, rheological evaluations DR-044.
Product Features
| HLR-1 | HLR-2 | HLR-3 | |
|---|---|---|---|
| HA concentration | 4 mg/mL | 6 mg/mL | 8 mg/mL |
| Primary indications | Lips correction & enhancement | Filling & smoothing of wrinkles | Facial remodeling & volume restoration |
| Elastin % (vs non treated skin)³ | +104% | +54% | +38% |
| Collagen I (% vs non treated skin)¹ | +14% | +21% | +20% |
| Lifting Force⁴ | c.460 Pa | c.1,175 Pa | c.1,950 Pa |
| Product Integration | Distributed | Distributed | Distributed |
| Syringe Volume | 1 mL | 1 mL | 1 mL |
| Needle | 30G (UTWN) | 27G (UTWN) | 27G (UTWN) |
| Microcannula Recommendation | 25G | 22G | 22G |
| Composition | 4 mg/mL HA with 0.3% Lidocaine | 6 mg/mL HA with 0.3% Lidocaine | 8 mg/mL HA with 0.3% Lidocaine |
(1) Hallura, data on file, study reports – 22E5690, 22E5830, Elastin and Collagen stimulation 7 days post injection in a Human skin explant.
(2) Hallura, data on file, rheological evaluations DR-044.
Product Features
| HLR-1 | HLR-2 | HLR-3 | |
|---|---|---|---|
| HA concentration | 4 mg/mL | 6 mg/mL | 8 mg/mL |
| Primary indications | Lips correction & enhancement | Filling & smoothing of wrinkles | Facial remodeling & volume restoration |
| Elastin % (vs non treated skin)¹ | +104% | +54% | +38% |
| Collagen I (% vs non treated skin)¹ | +14% | +21% | +20% |
| Lifting Force² | c.460 Pa | c.1,175 Pa | c.1,950 Pa |
| Product Integration | Distributed | Distributed | Distributed |
| Syringe Volume | 1 mL | 1 mL | 1 mL |
| Needle | 30G (UTWN) | 29G (UTWN) | 29G (UTWN) |
| Microcannula Recommendation | 25G | 22G | 22G |
| Composition | 4 mg/mL HA with 0.3% Lidocaine | 6 mg/mL HA with 0.3% Lidocaine | 8 mg/mL HA with 0.3% Lidocaine |
(1) Hallura, data on file, study reports – 22E5690, 22E5830, Elastin and Collagen stimulation 7 days post injection in a Human skin explant.
(2) Hallura, data on file, rheological evaluations DR-044.
WHY HALLURA?
The breakthrough technology utilized by Hallura™ sets it apart as innovative and revolutionary compared to existing technologies in the market, both in terms of production, safety, and the user experience of healthcare professionals utilizing Hallura’s products.
“Hallura™ products are excellent, the results last very long and the reactions post injections, such as swelling or pain, are minimal. The integration in the tissue is much better than usual, patients do not feel the products in their lips or skin and they love the very natural results. It’s certainly a great product, especially for treating lips in young patients.”
Dr. Elzbieta Kowalska-Oledzka, Warsaw, Poland
“A very soft, modern hyaluronic acid which is perfect for aesthetic use. The maintenance of the results over time is very good, even in the lips after 12 months.”
Dr. Rodrigo da Mota, Düsseldorf, Germany
Good tolerance from subject's self assessments
Subject reported very good tolerance to Hallura’s products range, with lower, more transient and less severe site reactions compared to products’ data published by market leaders.
(1)HALLURA European Clinical Study (19E2031), prospective, interventional, non-randomized, multi-centers, open-label study, on 132 patients for Lips enhancement, NLF correction and Cheeks enhancement. Compared to FDA, pivotal studies data on Market leaders.
HALLURA® European Clinical Study (19E2031) on 132 patients for Lips enhancement, NLF correction and Cheeks enhancement. Compared to FDA, pivotal studies data data on Market leaders. Patients self assesment within 14-days Injection Site Reactions diary, reaction lasting more than 8 days (#) No reported data.
HALLURA® European Clinical Study (19E2031) on 132 patients for Lips enhancement, NLF correction and Cheeks enhancement. Compared to FDA, pivotal studies data data on Market leaders. Patients self assesment within 14-days Injection Site Reactions diary, reaction lasting more than 8 days (#) No reported data.
WHY HALLURA?
Introduction:
The breakthrough technology utilized by Hallura™ sets it apart as innovative and revolutionary compared to existing technologies in the market, both in terms of production, safety, and the user experience of healthcare professionals utilizing Hallura’s products.
Good tolerance from subject's self assessments
Subject reported very good tolerance to Hallura’s products range, with lower, more transient and less severe site reactions compared to products’ data published by market leaders.
Data:
Testimonials:
“Hallura™ products are excellent, the results last very long and the reactions post injections, such as swelling or pain, are minimal. The integration in the tissue is much better than usual, patients do not feel the products in their lips or skin and they love the very natural results. It’s certainly a great product, especially for treating lips in young patients.”
Dr. Elzbieta Kowalska-Oledzka, Warsaw, Poland
“A very soft, modern hyaluronic acid which is perfect for aesthetic use. The maintenance of the results over time is very good, even in the lips after 12 months.”
Dr. Rodrigo da Mota, Düsseldorf, Germany
(1)HALLURA European Clinical Study (19E2031), prospective, interventional, non-randomized, multi-centers, open-label study, on 132 patients for Lips enhancement, NLF correction and Cheeks enhancement. Compared to FDA, pivotal studies data on Market leaders.
The Revolution
While All HA fillers are crosslinked, Hallura developed BiOLinkMatrix “lock-key” cross-linking, perfectly elastic compared to current HA in the market.
Current HA
- Damaging the HA polymer chains
- Losing elasticity
- Granular, harder materials
BioLinkMatrix
- Sustaining the long polymer chains
- Pure Elasticity
- Granular, harder materials
- Natural and Youthful look.
LONG-LAStING RESULTS
lONG-lASTING RESULTS
The Hallura Advantage in three steps
Our journey began with a commitment to develop dermal fillers that not only meet but exceed the expectations of individuals seeking aesthetics treatments.
Hallura employs BiOLinkMatrix, inspired by the 2022 Nobel Prize-winning Click Chemistry. This technology enables precise, minimal modification of native Hyaluronic Acid (HA) polymer through bio-orthogonal cross-linking.
The preserved natural HA chains are crucial for maintaining youthful skin properties, ensuring effective skin rejuvenation.
Bio Stimulation of Collagen 1 and 3 and Elastin
Utilizing a distinctive method, Hallura fosters targeted bio-stimulation, promoting the production of collagen types 1 and 3 along with elastin.
This cutting-edge technology positions Hallura as a leader in delivering effective solutions for skin improvement.
Natural and long-lasting results
Hallura’s products closely mimic youthful skin by preserving the natural properties of the HA biopolymer and minimizing side reactions. The gel’s adaptive elasticity integrates seamlessly, promoting bio-stimulation for a long lasting, natural appearance.
The emphasis on safety and natural outcomes through bio-Orthogonal chemistry distinguishes Hallura from competitors using harsh cross-linking methods in the dermal fillers market.
Hallura™ is praised for natural results and sensations by users:
Formal formularions, 3 indications.
“Very good tissue integration: It looks like tissue is thickening. You don’t feel the filler underneath the skin as usually. Tissue and filler become one”.
“Predictability. Super-forgiving product.”
“What you see is what you get”.
“More than excellent. Never had this experience in the lips with any product on the market.”
Source Company, quotes from clinical study stakeholders.
- Formal formulations, 3 indications.
- Primary endpoints passed with statiscal significance. Widely above the 60% sucess threshold.
- Secondary endpoints demonstrate effectiveness over study of 18 months (clear indication of durability over 15 months).
- Safety data demonstrate a strong safety profile of each of the products.
Hallura® praised1 for natural results and sensations
Formal formulations, 3 indications.
“Very good tissue integration: It looks like tissue is thickening. You don’t feel the filler underneath the skin as usually. Tissue and filler become one”.
“Predictability. Super-forgiving product.”
“What you see is what you get.”
“More than excellent. Never had this experience in the lips witth any product on the market.”
ELASTICITY &
BIOSTIMULATION
effectively more elastin and collagen new produce gels HLR by stimulated Fibroblasts
Human fibroblast culture in presence of HLR-2
-
Regeneration of young and high quality. Collagen:
+20% Collagen type III - High levels of Elastin: +75 Elastin
- LOW inflammatory and no specific oxidative DNA damage: no specific
BiOLinkMatrix Natural tissue Bio-stimulation
Hallura@’s HA collection stimulated the extracellular matrix by
enhancing the elastin and collagen networks.
COLLAGEN GENERATION
Hallura gels are more than a filler: Fibroblasts stimulated by HLR gels produce new collagen and elastin more effectively.
Human fibroblast culture in presence of Hallura HLR-2⁶
Natural tissue Bio-stimulation³
Hallura’s HA fillers stimulates the extracellular
matrix by enhancing the elastin and collagen networks.
Natural tissue Bio-stimulation³
Hallura’s HA fillers stimulates the extracellular matrix by enhancing the elastin and collagen networks.
HALLURA® Vs
COMPETITORS
BiOLinkMatrix – Clinical data demonstrates Best in Class Efficacy
Compared to the USUal observations made in clinical studies of the best products on the market
(1) BIOENX, Study report: Comparing dermal fibroblast responses after 48hrs of exposure to two hyaluronic acid dermal fillers with distinct cross-linking agents: An in vitro study.
(2) BioEC study reports – 22E5696, 22E5830 Elastin and Collagen I stimulation 7 days post injection in a Human skin explant.
Tissue Integration
Hallura ensures excellent tissue integration through its innovative technology, fostering seamless and natural assimilation with the body’s own tissue. This results in enhanced aesthetic outcomes, providing a harmonious blend for a more natural and radiant appearance.
- Superior Tissue Integration:
Hallura excels in tissue integration. Our technology minimizes the risk of foreign-body reactions, fostering a seamless and natural process. - Long-Term Safety:
Hallura’s advanced technology reduces the likelihood of adverse reactions, ensuring sustained well-being for our patients. - Natural Ingrowth Over Time:
The unique composition of BiOLinkMatrix favors natural tissue ingrowth, promoting a gradual and harmonious integration with surrounding tissues for enduring and natural results.
Tissue Integration
Hallura ensures excellent tissue integration through its innovative technology, fostering seamless and natural assimilation with the body’s own tissue. This results in enhanced aesthetic outcomes, providing a harmonious blend for a more natural and radiant appearance.
- Superior Tissue Integration:
Hallura excels in tissue integration. Our technology minimizes the risk of foreign-body reactions, fostering a seamless and natural process. - Long-Term Safety:
Hallura’s advanced technology reduces the likelihood of adverse reactions, ensuring sustained well-being for our patients. - Natural Ingrowth Over Time:
The unique composition of BiOLinkMatrix favors natural tissue ingrowth, promoting a gradual and harmonious integration with surrounding tissues for enduring and natural results.
BioLinkMatrix
12 Months Follow-Up demonstrates very high satisfaction from patients and physicians
SUBJECTS
Global Aesthetic Improvement – Subjects
EVALUATORS
Global Aesthetic Improvement – Independent Live Evaluators
80% of subjects and Independent Live Evaluators see improvement over 12 months
What Doctors Say
What Our Clients Say
More Testimonials
Marina Landau
References
1 – Typical conditions for BDDE crosslinking: 52’C for 3hrs.
2 – Optimized conditions for BDDE crosslinking: low temperature, several days.
3 – BioEC study reports – 22E5696, 22E5830 Elastin and Collagen I stimulation 7 days post injection in a Human skin explant.
4 – Hallura, data on file, rheological evaluations DR-044.
5 – Hallura European Clinical Study (19E2031) on 132 patients for lips enhancement, naso-labial folds correction and cheeks enhancement. Compared to FDA, pivotal studies data on Market leaders.
6 – BIOENX, Study report: Comparing dermal fibroblast responses after 48hrs of exposure to two hyaluronic acid dermal fillers with distinct cross-linking agents: An in vitro study.
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FAQ
Most frequent questions and answers
BiOLinkMatrix by Hallura™ is an innovative technology that redefines the landscape of hyaluronic acid (HA) dermal fillers. It employs a unique “lock-key” cross-linking method, providing perfectly elastic gels compared to current HA fillers in the market.
Traditional HA fillers are often cross-linked using methods that may result in harder, less elastic materials. Hallura’s BiOLinkMatrix, on the other hand, preserves the long polymer chains, ensuring pure elasticity for a more natural and youthful appearance.
Hallura’s advanced product line includes treatments for skin rejuvenation, fine and deep line smoothing, as well as volume restoration in lips and mid-face. Our products have undergone rigorous pre-clinical and clinical trials in Europe, demonstrating excellent efficacy and safety outcomes.
Hallura’s commitment to safety is rooted in its use of bio-orthogonal chemistry, allowing for exceptionally low modification of native HA polymers during the cross-linking process. Hallura’s end-to-end approach to products safety and quality applies to design, testing, manufacturing, controls and how our dermal fillers are experienced by users and patients.
Hallura has successfully conducted multi-site clinical trials in Europe and outside Europe, demonstrating excellent performance and safety across various facial treatment indications. The results indicate the potential of BiOLinkMatrix gels to reduce post-treatment reactions and meet the demand for effective and better-tolerated aesthetic treatments.
For inquiries you can contact us through email at info@hallura.com. We value fast and efficient support, ensuring a smooth experience for our clients.
Hallura’s aesthetic treatments are designed to deliver long-lasting results. The duration can vary based on the specific treatment and individual factors, but our commitment is to provide results that stand the test of time.
Preserving long chains in Hallura’s technology is crucial for maintaining the natural elasticity of hyaluronic acid (HA). This unique approach enhances the effectiveness of our dermal fillers for skin rejuvenation.
Hallura’s technology fosters bio-stimulation of collagen by promoting the natural production of collagen types 1 and 3 and elastin. This contributes to skin rejuvenation, providing long-lasting and natural-looking results.
Hallura’s commitment to preserving the innate properties of the biopolymer, such as long polymer chains, ensures a natural look and feel in our dermal fillers. This focus on purity and elasticity distinguishes Hallura from other products.
Join us for a new standard in aesthetics.
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Beit Apollo, Yoqneam 20692, Israel
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