Our Technology

Explaining the technology

Innovative Solutions, Long-Lasting Results: Explore Hallura's Cutting-Edge Technology

Pioneering HA Fillers Excellence: Crafting Innovations to Shape the Future of Beauty.

Hallura offers a new horizon of aesthetic medicine that is safe, innovative, and natural. Our cutting-edge technology, coupled with our team’s expertise, provides you with personalized treatments and long-lasting results.

Play Video

Our Revolutionary
Technology:
BioLinkMatrix

At Hallura, we’ve redefined the landscape of hyaluronic acid (HA) dermal fillers through our groundbreaking technology known as BioLinkMatrix. This innovative approach represents a significant leap forward in the field of aesthetic medicine, offering a unique solution for those seeking natural, safe, and long-lasting results.

With a foundation rooted in successful clinical trials and a steadfast commitment to natural beauty, safety, and effectiveness, Hallura’s BioLinkMatrix emerges as a guiding light for individuals seeking personalized, adaptive, and confidence-boosting aesthetic treatments.

WE ARE

FILLERS HA

BASED ON THE 2022 NOBEL PRIZE IN CHEMISTRY
FIRST TIME INTRODUCED TO THE AESTHETIC FIELD

BASED ON THE 2022 NOBEL PRIZE IN CHEMISTRY

FIRST TIME INTRODUCED TO THE AESTHETIC FIELD

WHY HALLURA?

The breakthrough technology utilized by Hallura® sets it apart as innovative and revolutinary compared to existing technologies in the market, both in terms of production, safety, and the user experience of healthcare professionals ultilizing Hallura’s products.

“Hallura® products are excellent, the results last very long and the reactions post injections, such as swelling or pain, are minimal. The integration in the tissue is much better than usual, patients do not feel the products in their lips or skin and they love the very natural results. It’s certainly a great product, especialy for treating lips in young patients.”

Dr. Elzbieta Kowalska-Oledzka, Warsaw, Poland

“A very soft, modern hyaluronic acid which is perfect for aesthetic use. The maintenance of the results over time is very good, even in the lips after 12 months.”

Dr. Rodrigo da Mota, Düsseldorf, Germany

Good tolerance from subject's self assessments

Very good tolerance to Halluras™ range, with lower, more transient and less severe site reaction reported by the subject treatment, compared to market leaders’s data.

(1) Hallura European Clinical Study (19E2031) on 132 patients for Lips enhancement, NLF correction and Cheeks enhancement. Patient diary data following lips enhancement with HLR-1; compared to FDA, pivotal studies data on Market leaders (Volbella P110033/S018, Restylane Kysse P140029/S018, Restylane Silk P040029/S072, RHA-3 P170002/S030, Juvederm Ultra XC P050047/S044, Restylane L P040024/S056.). Patients self assessment within 14-days Injection Site Reactions diary, reaction lasting more than 8 days.

HALLURA® European Clinical Study (19E2031) on 132 patients for Lips enhancement, NLF correction and Cheeks enhancement. Compared to FDA, pivotal studies data data on Market leaders. Patients self assesment within 14-days Injection Site Reactions diary, reaction lasting more than 8 days (#) No reported data.

The Revolution

While All HA fillers are crosslinked, Hallura developed BiOLinkMatrix “lock-key” cross-linking, perfectly elastic compared to current HA in the market.

Current HA

  • Damaging the HA polymer chains
  • Losing elasticity
  • Granular, harder materials

BioLinkMatrix

  • Sustaining the long polymer chains
  • Pure Elasticity
  • Granular, harder materials
  • Natural and Youthful look.

LONG-LAStING RESULT'S

lONG-lASTING RESULTS

The Hallura Advantage in three steps

Our Journey began with a commitment to creating dermal fillers that not only meet but exceed the expectations of individuals seeking aesthetics treatments.

Sustaining the long polymer chains

Hallura employs BioLinkMatrix, inspired by the 2022 Nobel Prize-winning Click Chemistry. This technology enables precise, minimal modification of native Hyaluronic Acid (HA) polymer through bio-orthogonal cross-linking.

The preserved natural HA chains are crucial for maintaining youthful skin properties, ensuring effective skin rejuvenation.

Bio Stimulation of Collagen 1 and 3 and Elastin

Utilizing a distinctive method, Hallura fosters targeted bio-stimulation, promoting the production of collagen types 1 and 3 along with elastin. 

This cutting-edge technology positions Hallura as a leader in delivering effective solutions for skin rejuvenation.

Natural and long-lasting results

Hallura’s products closely mimic youthful skin by preserving the natural properties of the HA biopolymer and minimizing side reactions. The gel’s adaptive elasticity integrates seamlessly, promoting bio-stimulation for a lasting, natural appearance.

This emphasis on safety and natural outcomes through bio-orthogonal chemistry distinguishes Hallura from competitors using harsh cross-linking methods in the dermal fillers market.

CLINICAL STUDY HIGHLIGHTS

Efficacy and duration of Halluras®’s targeted portfolio

Hallura® praised1 for natural results and sensations
Formal formulations, 3 indications.

“Very good tissue integration: It looks like tissue is thickening. You don’t feel the filler underneath the skin as usually. Tissue and filler become one”.

“Predictability. Super-forgiving product.”

“What you see is what you get.”

“More than excellent. Never had this experience in the lips witth any product on the market.”

Source Company
Note Assessed by clinical study stakeholders

ELASTICITY & BIOSTIMULATION

effectively more elastin and collagen new produce gels HLR by stimulated Fibroblasts

Human fibroblast culture in presence of HLR-2

BiOLinkMatrix Natural tissue Bio-stimulation

Hallura@’s HA collection stimulated the extracellular matrix by
enhancing the elastin and collagen networks.

BIOENIX, Study report: Comparing dermal fibroblast responses after 48hrs of exposure to two hyaluronic acid dermal fillers with distinct cross-linking agents: An in vitro study. Host (fibroblasts) response to the dermal filler used in the test.
BioEC study reports – 22E5696, 22E5830. Elastin and Collagen I stimulation 7 days post injection in a Human skin explant.

COLLAGEN GENERATION

Hallura gels are more than a filler: Fibroblasts stimulated by HLR gels produce new collagen and elastin more effectively.

Human fibroblast culture in presence of HLR-21

Natural tissue Bio-stimulation²

Hallura’s HA collection stimulates the extracellular 

matrix by enhancing the elastin and collagen networks.

(1) BIOENX, Study report: Comparing dermal fibroblast responses after 48hrs of exposure to two

hyaluronic acid dermal fillers with distinct cross-linking agents: An in vitro study.

(2) BioEC study reports – 22E5696, 22E5830 Elastin and Collagen I stimulation 7 days post injection in a Human skin explant.

HALLURA® Vs COMPETITORS

BiOLinkMatrix – Clinical data demonstrates Best in Class Efficacy

Excellent efficacy at 12 months
Compared to the USUal observations made in clinical studies of the best products on the market

HALLURA European Clinical Study (19E2031), prospective, interventional, non-randomized, multi-centers, open-label study, on 132 patients for Lips enhancement, NLF correction and Cheeks enhancement. Compared to FDA, pivotal studies data on Market leaders.

Tissue Integration

Hallura ensures excellent tissue integration through its innovative technology, fostering seamless and natural assimilation with the body’s own tissue. This results in enhanced aesthetic outcomes, providing a harmonious blend for a more natural and radiant appearance.

  • Superior Tissue Integration:
    Hallura excels in tissue integration. Our technology minimizes the risk of foreign-body reactions, fostering a seamless and natural process.

  • Long-Term Safety Assurance:
    With high potential for superior long-term safety, Hallura’s advanced technology reduces the likelihood of adverse reactions, ensuring sustained well-being for our patients.

  • Natural Ingrowth Over Time:
    The unique composition of BiOLinkMatrix favors natural tissue ingrowth, promoting a gradual and harmonious integration with surrounding tissues for enduring and natural results.

BioLinkMatrix

12 Months Follow-Up demonstrates very high satisfaction from patients and physicians

SUBJECTS

Global Aesthetic Improvement – Subjects

EVALUATORS

Global Aesthetic Improvement – Independent Live Evaluators

80% of subjects and Independent Live Evaluators see improvement over 12 months

Subscribe for updates

Subscribe to Hallura and stay ahead of the latest trends in the world of aesthetics!

FAQ

Most frequent questions and answers

Hallura’s BiOLinkMatrix is an innovative technology that redefines the landscape of hyaluronic acid (HA) dermal fillers. It employs a unique “lock-key” cross-linking method, providing perfectly elastic results compared to current HA fillers in the market.

Traditional HA fillers are often cross-linked using methods that may result in reduced natural elasticity. Hallura’s BiOLinkMatrix, on the other hand, preserves the long polymer chains, ensuring pure elasticity for a more natural and youthful appearance.

Hallura’s advanced product line includes treatments for skin rejuvenation, fine and deep line smoothing, as well as volume restoration in lips and mid-face. Our products have undergone rigorous pre-clinical and clinical trials in Europe, demonstrating excellent efficacy and safety outcomes.

Hallura’s commitment to safety is rooted in its use of bio-orthogonal chemistry, allowing for exceptionally low modification of native HA polymer during the cross-linking process. This preserves the innate properties of the biopolymer, ensuring safety and natural outcomes.

Hallura has successfully conducted multi-site clinical trials in Europe, demonstrating excellent performance and safety across various facial treatment indications. The results indicate the potential of BioLinkMatrix gels to reduce post-treatment reactions and meet the demand for effective and better-tolerated aesthetic treatments.

For inquiries or to schedule a consultation, you can contact us through email at hallura@hallura.com. We value fast and efficient support, ensuring a smooth experience for our clients.

Hallura’s aesthetic treatments are designed to deliver long-lasting results. The duration can vary based on the specific treatment and individual factors, but our commitment is to provide results that stand the test of time.

Preserving long chains in Hallura’s technology is crucial for maintaining the natural elasticity of hyaluronic acid (HA). This unique approach enhances the effectiveness of our dermal fillers for skin rejuvenation.

Hallura’s technology fosters bio-stimulation of collagen by promoting the natural production of collagen types 1 and 3. This contributes to skin rejuvenation, providing long-lasting and natural-looking results.

Hallura’s commitment to preserving the innate properties of the biopolymer, such as long polymer chains, ensures a natural look and feel in our dermal fillers. This focus on purity and elasticity distinguishes Hallura from other products.

Our HA Fillers provide superior, lasting beauty.

Join us for a new standard in aesthetics.

Company

HaCarmel St. 67, Beit Apollo
POB 128, Yoqneam 2069202, Israel

News

Contact Us